Atletico Madrid striker Alvaro Morata scored a goal and then missed a penalty as his side began their La Liga campaign with an eventful and nervy 1-0 win at home to Getafe on Sunday which saw both teams reduced to 10 men.
Second half goals from Presnel Kimpembe and Kylian Mbappe gave the impressive French side a clear advantage ahead of the return in Paris on March 6.
Ousmane Dembele struck early and Lionel Messi converted a late penalty as Barcelona won 2-0 at Juventus in the Champions League on Wednesday after Alvaro Morata had three goals disallowed for offside for the Serie A side.
Real Madrid's teenage Brazilian duo Vinicius Junior and Rodrygo Goes sent them top of La Liga as both scored in a 2-0 win over Osasuna on Wednesday.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
IMAGES from the English Premier League matches played on Saturday.
Images from Sunday's Premier League action.
News of all that's transpired on and off the football field
Napoli began their Europa League group stage campaign in scintillating fashion.
IMAGES from the English Premier League matches played on Sunday.
IMAGES from the EPL matches played on Saturday
A summary of Wednesday night's action in the UEFA Champions League.
IMAGES from the Champions League matches played on Wednesday
Images from the football matches played across Europe on Sunday.
Brighton & Hove Albion scored three times in the second half to fight back from two goals down and beat Manchester City
IMAGES from the English Premier League matches played on Saturday.
Liverpool handed their fiercest rivals a painful lesson on Thursday with a dominant 2-0 win over Manchester United in the first leg of a Europa League last-16 clash.
News of all that transpired on and off the football field.
Eden Hazard finally scored his first goal for Real Madrid as his side beat second-placed Granada 4-2 in a highly entertaining game at the Santiago Bernabeu on Saturday to go four points clear at the top of La Liga.
Ronaleo netted his 14th league goal for Juve this season while PSG's winning streak was snapped by Monaco in a 3-3 draw. Here are images from the matches played on Sunday
IMAGES from the English Premier League matches played on Saturday.
Images from the UEFA Champions League matches on Tuesday night.
Lionel Messi was at the top of his game as Barcelona earned a 3-2 win at Athletic Bilbao on Wednesday to move up to third in La Liga.
A round-up of Saturday's action in the Premier League.
Images from the English Premier League matches played on Saturday.
News of all that's transpired on and off the football field.
Neymar made his return to the pitch after a three-month injury lay-off as Paris St Germain celebrated their eighth Ligue 1 title with a 3-1 win against Monaco at the Parc des Princes on Sunday.
IMAGES from the English Premier League matches played on Saturday
Celta Vigo thrashed Barcelona 4-1 on Wednesday with Iago Aspas hitting a double.
A round-up of Tuesday's action in the UEFA Champions League.
IMAGES from Premier League matches played on Saturday.
A summary of Saturday's action in Ligue 1, La Liga and Serie A.
Lionel Messi fittingly sealed Barcelona's 26th La Liga title on Saturday by coming off the bench to score the goal in a 1-0 win over Levante in front of a jubilant Nou Camp crowd, who celebrated a remarkable eighth league crown in 11 years.
Images from Saturday's action in the English Premier League.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
News that transpired on and off the football field.
A round-up of Saturday's action in the Premier League.
Juve forward Cristiano Ronaldo had an unusually quiet game after scoring a hat-trick against Atletico in last year's competition, although he came within inches of grabbing a last-gasp winner when he sent a shot just past the far post.